09/2008 - 06/2012：北京化工大学理学院应用化学系，理学学士 [导师：许家喜教授]

2012/09 - 2017/05：美国东北大学化学及化学生物学学院，博士 [导师：Ke Zhang (张可) 教授]

2017/08 - 2020/11：美国麻省理工学院David H. Koch癌症研究所，博士后 [导师：Robert S. Langer]

2020/12 - 至今：   中国科学院化学研究所，研究员

课题组的研究思路是以设计合成新型化学材料为核心，构建具有独特性质的递送系统，目标是解决生物、医学、及临床上的问题。我们通过了解临床医学上的具体问题来指导我们的材料设计，希望在材料和药物递送系统方面能够解决基础的科学问题，在解决临床问题的过程中能够实现科研成果的转化。

课题组目前具体的研究方向有：

一、 吸入mRNA疫苗与药物

二、 肠道免疫mRNA递送载体

三、 核酸载体与生物界面相互作用

1. 国家自然科学基金优秀青年科学基金项目（海外），主持

2. 中国科学院战略性先导科技专项（B类），项目负责人

3. 国家自然科学基金面上项目‌，主持

4. 中科院全球共性挑战专项，主持

1. Li J., Liu Y., Ma X., Liu S., Yang C., Zhang Y., Cheng X., Wen Y., Mi S., Zu H., Li W., Zhao Y., Li Q., Liu S., Huo H., Shi G., Lu X.* Parenteral vaccination with an adjuvanted mRNA vaccine induces protective mucosal immunity against rotavirus in neonatal mice. Sci. Transl. Med. 2026, 18, eadw6105

2. Lu, X.†, Miao, L.†, Gao, W., Chen, Z., McHugh, K., Sun, Y., Tochka, Z., Tomasic, S., Sadtler, K., Hyacinthe, A., Huang, Y., Graf, T., Hu, Q., Sarmadi, M., Langer, R.*, Anderson, D.*, Jaklenec, A.* Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy. Sci. Transl. Med. 2020, 12, eaaz6606.

3. Cheng, X., Zheng, X., Tao, K., Huo, H., Liu, Z.*, Lu, X.*, Wang, J*. Freezing induced incorporation of betaine in lipid nanoparticles enhances mRNA delivery. Nat. Commun., 2025, 16, 4700.

4. Liu, S., Wen, Y., Shan, X., Ma, X., Yang, C., Cheng, X., Zhao, Y., Li, J., Mi, S., Huo, H., Li, W., Jiang, Z., Li, Y., Lin, J., Miao, L., Lu, X.* Charge-assisted stabilization of lipid nanoparticles enables inhaled mRNA delivery for mucosal vaccination. Nat. Commun., 2024, 15, 9471.

5. Cheng X., Li Q., Zu H., Liu S., Li J., Wen Y., Yang C., Sun S., Lu H., Zhang Y., Zhao Y., Shi G., Qin M., Lu X. N-Acetylcysteine–Mediated Surface Remodeling of Inhaled mRNA Lipid Nanoparticles Enables Coordinated Mucosal and Systemic Antitumor Immunity. Adv. Mat., 2026, e73362.

6. Cheng, X.†, Liu, S.†, Sun, J.†, Liu, L., Ma, X., Li, J., Fan, B., Yang, C., Zhao, Y., Liu, S., Wen, Y., Li, W., Sun, S., Mi, S., Huo, H., Miao, L., Pan, H., Cui, X.*, Lin, J.*, Lu. X.* A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges. Adv. Mater., 2023, 2310886.

7. Lu, X.†, Fu, H.†, Shih, K.-C., Jia, F., Sun, Y., Wang, D., Wang, Y., Ekatan, S., Nieh, M.-P.*, Lin, Y.*, Zhang, K.* DNA-mediated step-growth polymerization of bottlebrush macromonomers. J. Am. Chem. Soc. 2020, 142, 10297-10301.

8. Lu, X., Jia, F., Tan, X., Wang, D., Cao, X., Zheng, J., Zhang, K.* Effective antisense gene regulation via non-cationic, polyethylene glycol brushes.J. Am. Chem. Soc. 2016, 138, 9097-9100.

9. Lu, X., Tran, T.H., Jia, F., Tan, X., Davis, S., Krishnan, S., Amiji, M.M., Zhang, K.* Providing oligonucleotides with steric selectivity by brush polymer-assisted compaction. J. Am. Chem. Soc. 2015, 137, 12466-12469.

10. Huo H., Zhai J., Li J., Chen N., Han J., He X.*, Mao J.*, Lu X.* Fluorinated Lipid Probes Unveil the Molecular Basis of Tail-Chain Regulation in Lipid Nanoparticles. CCS Chem. 2026. DOI: 10.31635/ccschem.026.202607519.